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Lipogenesis Inhibition: In adipose tissue, NNMT inhibition reduces lipid accumulation by up to 70% (in vitro), shifting the cell's priority from fat storage to energy expenditure

NAD+ restoration in dermal fibroblasts lowers the number of aging cells and activates SIRT1-mediated autophagy pathways

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They have realistic expectations: they are not expecting a return to the early dramatic phase of GLP-1 weight loss, but rather a renewed period of modest progress through what would otherwise be a flat curve