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Conditions such as osteoarthritis may require major changes in daily routine and introduce strong motivation for compliance (3)

Stop or pause the protocol if persistent headaches, glucose spikes, vision changes, or carpal tunnel symptoms appear

Post-hoc power calculations (G*Power 3.1) using the reported effect sizes (Cohens d 0.250.40) indicate that 80% power to detect a minimal clinically important difference of 1 cm on the VAS pain scale would require 128200 completers per arm

Within 90 minutes of ingestion, cellular glutathione levels were seen to substantially increase reaching maximum levels after two to three hours, before returning to basal levels by five to 6 hours