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doi: 10.1016/j.molimm.2020.08.007 98 PiresD.ValenteS.CaladoM.MandalM.Azevedo-PereiraJ

- Computed tomography (CT) of the brain that is normal in most patients with primary hypothyroidism (although long-lasting hypothyroidism promotes atherogenesis and, then, ischemic encephalopathy), and generally detects pituitary macroadenoma or an empty sella in patients with secondary hypothyroidism

This method failed to determine genotype in three samples, and these were genotyped by CLIPTM sequencing (Bayer Reference Testing Laboratory, Berkeley, CA)

Single-cell and spatial transcriptomics, longitudinal multi-omics, ncRNA, epigenomic profiling, and biomarker co-localization with disease are all necessary to close these gaps