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Genetic polymorphisms in genes encoding matrix metalloproteinases, collagen synthesis enzymes, or inflammatory mediators could theoretically influence GHK-Cu responsiveness, though systematic investigations of pharmacogenetic determinants remain absent from current literature

475,476 Chronic hyperglycemia-induced neuronal damage to the autonomic fibers innervating the bladder and genitalia leads to impaired neurotransmission

To date, there are no scientific studies that support this claim suggesting that further research in this area may be warranted

Enteric nervous system damage caused by abnormal intestinal butyrate metabolism may lead to functional constipation