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B12 absorption in the gut depends on a protein called intrinsic factor, which declines with age and can be compromised by certain medications and digestive conditions

Some have decades of laboratory work behind them

Such people have made the assertion that grain-fed livestock was more likely to get B12-deficient because such a diet, would make animals have a lower rate of B12 production. In other words, there is a belief out there that grain-fed cattle are not producing enough vitamin B12 in their rumen regardless if theyre getting sufficient cobalt in their diet

Caution is advised when glutathione is administered concurrently with these medications, as it may alter their metabolism or pharmacodynamics