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Aside from antioxidant metabolism and regulation in response to elevated ROS, cells also recruit components of the DNA damage response (DDR) pathway to cope with the potential damaging effect of free radicals on DNA 29,43

Kim AL, Zhu Y, Zhu H, Han L, Kopelovich L, Bickers DR, Athar M (2006) Resveratrol inhibits proliferation of human epidermoid carcinoma A431 cells by modulating MEK1 and AP-1 signalling pathways

But for targeted fat metabolism without systemic endocrine changes, AOD-9604 s selective profile makes it a distinctive and valuable option

Fourth, ZZ1 induced ternary complex formation slowly in biochemical assays when compared to ZZ1-SO 2 H (Extended Data Fig