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FIGURE 1 The levels of cellular nutrients (amino acids, glucose, certain lipids, and likely other metabolites) are sensed and signaled by an expanding number of proteins (SESNs, CASTOR, KICSTOR, SAMTOR, GATOR1 and 2) (Saxton and Sabatini, 2017) that culminate in the control of the guanosine phosphate state of the members of the Rag family of GTPases, which bind mTORC1 in a nutrient-sensitive manner (Figure 1)

10.1111/j.1365-2982.2010.01664.x 94 CuiL.LiS.WangS.WuX.LiuY.YuW.et al

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