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Following previous suggestions from the reviewer, to strengthen this aspect of the study, we performed two relevant and demanding experiments: (1) a new experiment using 30 additional adult mice to genetically label and quantify the newly formed OLs in the lesion area, using the pro-myelinating compound clemastine as positive control

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Numerous incidences have occurred when a high dose of Vitamin B12 (in the form of supplements or injections) has caused acne breakouts in susceptible or even healthy individuals

Reclast is contraindicated in patients with creatinine clearance less than 35 mL/min and in those with evidence of acute renal impairment