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(2017) reported that long-term culture of HepG2 and Huh7 cells under physiological hypoxia (8% O) increased intracellular ROS and p66^Shc, correlating with greater migration, metabolic flexibility, and oxidative-stress resistance, hallmarks of an aggressive HCC phenotype [90]

Commonly reported side effects are minimal and might include mild irritation or redness at the injection site

In 2021, the FDA's own advisory panel voted almost unanimously against approving Biogen's Alzheimer's drug Aduhelm, saying the evidence wasn't there