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5.4 Huntingtons disease HD, an autosomal dominant genetic disorder, is primarily caused by the expansion of CAG trinucleotide repeats in the huntingtin ( HTT ) gene (Mollica et al., 2016

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Within the TME's boundaries, Treg cells exert control over T cells, NK cells, MDSCs, and macrophages through humoral and intercellular interactions, while also producing molecules like cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), IL-2, IL-10, and TGF-, contributing to the management of immunosuppression [88]