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In contrast, if the receptor is preferentially directed towards the lysosomal compartment, internalization leads to prolonged desensitization due to its proteolytic degradation [47, 48]

Zheng, S

Its non-synthetic profile and the fact that it's backed by research reassures users who aim to reduce reliance on over-the-counter painkillers, making it a confident addition for those who are less inclined to experiment with complex supplements