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Contrasting meta-analyses suggested otherwise

To determine whether KYN secretion is unique to PAT or adipose tissue in general, we compared PAT from MC38 tumour-bearing mice with contralateral iWAT (normal white adipose tissue (WAT)), analysing both tissue samples and their corresponding conditioned media

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Moreover, a key challenge is balancing the desired anti-tumor immune effects with potential systemic metabolic side effects, such as dyslipidemia, which has been observed with some FXR agonists (132)