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doi: 10.1385/JMN:23:3:189 92 HuangY

Future research should continue to explore the potential of IGFBP and IGFBP proteases as biomarkers and therapeutic targets for AD, and attempt to restore the brains IGF signaling pathway by modulating the abnormal expression of IGFBP and IGFBP proteases in AD

Safety, tolerability, and pharmacodynamics of intrathecal injection of recombinant human HGF (KP-100) in subjects with amyotrophic lateral sclerosis: a Phase I trial