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To further validate the specificity of the kinase inhibitors we analyzed known substrates of the individual kinases and found good reproducibility in our dataset (Fig

However, acute overdoses and long-term treatment can cause hepatotoxicity

Many efforts are focused on the identification of molecules and pathways to treat these conditions

The reaction mixture was poured into the dialysis membrane (Molecular weight cutoff 12 kDa) and dialyzed for 3 days in deionized water, the excess EDC.HCl, NHS, and unreacted proline were removed, then the CS-g-P were freeze-dried at -40 C and kept for further reaction