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We investigated quasispecies characteristics within three major genomic variation categories: viral complexity (quantified by Shannon entropy [SE]) of the Core gene, proportion of a protective combination of SNVs associated with HCC (protective-SNVs), and proportion of a combination of splicing variants (SP combination)

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2.10 Quantification of Endogenous SA Content The content of SA was determined using the method of (Enyedi et al

The V-rescale thermostat with two coupling groups was used to maintain the temperature of the system, and the Parrinello-Rahman barostat was used to maintain the pressure of the system