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As the fragment ion intensity and iRT prediction have different forms of input and output, we adopted separate designs for the embedding and regression network in those two tasks

Recent studies have validated this general approach demonstrating that molecules designed around angiotensin IV (Yamamoto et al, 2010) or the hinge sequence itself (Kawas et al., 2011) can bind HGF, block its dimerization, and attenuate HGF-dependent cellular actions