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Fandrey J, Seydel FP, Siegers CP, Jelkman W: Role of cytochrome P450 in the control of the production of erythropoietin

Published rodent protocols typically use subcutaneous or intraperitoneal injection in saline vehicle, dosed in pulsed courses (for example 1 g/kg daily for 10 days, repeated quarterly)

Notably, conditioned medium from PAT of patients with CRC and MC38 tumour-bearing mice contained 124 M and 97 M KYN, respectively (Supplementary Table 3)