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doi: 10.3389/fphar.2021.711500 Received 18 May 2021 Accepted 10 August 2021 Published 24 August 2021 Volume 12 - 2021 Edited by Jan Tack, University Hospitals Leuven, Belgium Reviewed by Duygu Aagndz, Gazi University, Turkey Carmelo Scarpignato, University of Parma, Italy Updates Copyright 2021 Camilleri and Atieh