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In aged mice, treatment with 5-amino-1mq combined with exercise produced remarkable results

Together, our observations that a small molecule NNMT inhibitor can increase NAD + and SAM concentrations in differentiated adipocytes and reduce adiposity in DIO mice, suggest that treatment with an NNMT inhibitor effectively reverses obesity via modulation of the NAD + salvage and SAM-mediated (e.g., polyamine flux) pathways to regulate energy expenditure in the adipose tissue

5-Amino-1MQ inhibits NNMT to theoretically raise NAD+ levels, though human evidence is absent