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Description

The RNA-dependent RNA polymerase (NSP12) and helicase (NSP13) of the replication-transcription complex (RTC) are the most conserved proteins when considering the rate of change at each amino acid site (homologies or nucleic acid diversity) over the course of the SARS-CoV-2 pandemic or conservation in sequence across HCoVs and the coronavirus family [62]

For PDT, both IR820 and catalase were encapsulated in PLGA NPs to reach the MV3 melanoma cell line intravenously in the BALB/c nude mice at 68 weeks of age [196]