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[6] Caution is also needed when using them with alpha-blockers and in patients with recent stroke or myocardial infarction

lowest tolerated dose Phase Step 2 Weeks Weeks 5-8 Cagrilintide Dose 0.5 mg/week Purpose Dose escalation Phase Step 3 Weeks Weeks 9-12 Cagrilintide Dose 1.0 mg/week Purpose GI side effects often peak here Phase Step 4 Weeks Weeks 13-16 Cagrilintide Dose 1.7 mg/week Purpose Approaching maintenance Phase Maintenance Weeks Weeks 17+ Cagrilintide Dose 2.4 mg/week Purpose Target dose used in late-stage study protocols Each step lasts 4 weeks

Final Thoughts CagriSema at C$145.00 (C$14.50/mg) sits at the higher end of the per-mg range of Durham Peptides' metabolic catalog, and the reason is mechanistic, not arbitrary: it's a two-component blend, and cagrilintide is the harder peptide of the two to manufacture at research grade

Most peptides require specialized transport mechanisms or fail to cross the BBB entirely when administered peripherally, but Dihexa achieves therapeutic CNS concentrations through standard subcutaneous or oral routes