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Macrophages exist in two primary "modes" or "polarizations": M1 Macrophages (The Demolition Crew): During the immediate aftermath of an injury, macrophages adopt the M1 state

IM injection is generally preferred for larger injection volumes (typically 0.5-2mL) as muscle tissue accommodates greater fluid volumes with less discomfort than subcutaneous fat

Stage 4.1 Stage 4.1 of the HC roadmap is ongoing

It has been demonstrated that at least 10 bacteria per microcolony on endothelial cells are needed to induce the recruitment of ezrin and the consequent cytoskeletal remodeling leading to the internalization of the bacteria (Soyer et al., 2014)