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MOR MOR, a primary target for pain management, has been extensively studied structurally, providing valuable insights into its activation mechanism and specific ligand recognition 31,119121

At the same time, conditions like obesity and physical inactivity contribute to respiratory dysfunction by altering chest wall mechanics and fostering a state of chronic inflammation

Moreover, we observed a direct effect of metformin on glutamate transporters, where the compound prevented glycation, by facilitating enzymatic phosphorylation close to Lys residues, suggesting a new neuroprotective role of metformin via PKC in preventing dysfunction in glutamatergic system induced by MG

In animals treated with HP, significantly increased activity of GST was observed