why use cd38 inhibitor with 5-amino-1mq blocks an enzyme called NNMT, and the mechanism is real, but NNMT overexpression does not track body fat. It tracks insulin resistance. Non-diabetic individuals at BMI 33 had normal NNMT. And Selective and membrane-permeable small molecule

Selective and membrane permeable small molecule inhibitors of nicotinamide N methyltransferase reverse high fat diet induced obesity in mice PMC Immunomodulatory properties of CD38 antibodies and their effect on anticancer efficacy in multiple myeloma Bisht 2023 Cancer Medicine Wiley Online Library Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice Scientific Reports CD38 Antibodies in Multiple Myeloma: Mechanisms of Action and Modes of Resistance Frontiers

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