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Mol Cell Biochem 340:283289

Myocarditis and pericarditis are characterized by the sudden onset of flu-like symptoms accompanied by: Chest pain or discomfort A feeling of tightness in the chest Shortness of breath during activity or when lying down Unusual tiredness Heart palpitations Lightheadedness or fainting Symptoms of vaccine-induced myocarditis or pericarditis typically require hospitalization to monitor for rare but potentially deadly complications like cardiac arrhythmia (irregular heartbeats) and cardiac arrest (in which the heart suddenly stops beating)

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Both PHGDH and SHMT1/2 are rate-limiting enzymes in their respective pathways and play crucial roles in tumorigenesis