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Supplemented GSH has been reported to hasten the ripening process [90] but the cellular reactions describing the role have not been ascertained

These discrepancies might be explained and reconciled by recent studies, which demonstrated that after amino acid deprivation, the proteasome moves from its predominant location in the nucleus to the cytoplasm, promoting protein degradation in the cytoplasm and thereby supplying the amino acids necessary for cell survival

IDH1 mutations are common genetic abnormalities in human malignancies

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