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As a word of caution, our understanding of the main forces involved in fibrosis, namely in SSc skin fibrosis, remains imprecisely defined

Additionally, treatments such as Microbiota Transfer Therapy (MTT), focused on gut microbiota regulation, have shown promising results by improving ASD-related symptoms in patients that were sustained after finishing the treatment (Kang et al., 2019)

It has been established that several mechanisms may contribute to the dysfunction of HBV-specific T cells, such as continuously high viral load and high antigen levels, suppressive cytokines including interleukin-10 (IL-10) and transforming growth factor- (TGF- ), dendritic cells (DCs) and regulatory T (Treg) cells, which were able to result in a progressive loss of T-cell function and cause HBV-specific T cells to become exhausted 7, 8 (Figure 1)