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The activation of Nrf2 and stimulation of downstream antioxidants and phase II detoxification enzymes expression suggest that these natural bioactive compounds represent a potential therapeutic source for prevention and treatment of CVDs

(50) studied promoter methylation of the Nitric Oxide Synthase 3 ( NOS3) and Endothelin 1 ( EDN1) genes in steel workers and reported an inverse correlation between NOS3 methylation exposure to PM 10 , while EDN1 methylation showed a similar negative correlation with zinc exposure