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All data were normalized to -actin and GAPDH expression and are given relative to control (control=1, not shown in figure)

Our bodies produce glutathione naturally, but various factors, including poor diet, environmental toxins, and stress, can deplete its levels

The proposed GND combination (guanfacine, NAC, donepezil) leverages distinct and complementary mechanisms of action, with minimal risk of drugdrug interactions, offering a comprehensive and well-tolerated therapeutic strategy for addressing the complex and chronic neurocognitive sequelae of sTBI (Figure 1)