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An RDP multicenter study from 2008 showed that Pycnogenol supplementation significantly reduced abdominal discomfort in women with dysmenorrhea ( for two menstrual cycles, during which they needed significantly less analgesic medication than in the registration period of two months before supplementation (46%) and less than placebo controls (28%)

Similarly, the overexpression of DHAR enhances salt tolerance in rice, Arabidopsis , and tobacco (Kwon et al., 2003

Zhou S, Zhang X, Ni W, He Y, Li M, Wang C, et al

"Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline." Annals of Internal Medicine , 173(10):805-821