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However, how this change arises and contributes to HD pathogenesis is unclear

[32] : 355359 Adverse effects [edit] Pain [edit] Placement of an intravenous line inherently causes pain when the skin is broken and is considered medically invasive

Recent research supports a prion-like propagation model, where pathogenic -synuclein spreads trans-neuronally via exosomes and synaptic transmission, initiating a chain reaction of misfolding across interconnected brain regions