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10.1038/nature10167 Nature 152 RavindranJ.PrasadS.AggarwalB

6 The potential of ferroptosis in PD early diagnosis It is estimated that by the time motor deficits are detected and individuals with PD receive a clinical diagnosis, they may have lost 3050% of their dopaminergic neurons, accompanied by a 5060% reduction in striatal dopamine (212), underscoring the critical need for early diagnosis in PD treatment

The comparatively high values for Vss of free cobalamins-(III) are due to the high protein binding of hydroxocobalamin as it reacts in the blood with plasma constituents to form cobalamins-(III) complexes and the rapid distribution of free cobalamins-(III) into tissues