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Diabetic patients with conventional subcutaneous insulin therapy had lower IGF-1 levels than patients with continuous subcutaneous insulin infusion and intraportal insulin infusion [13]

Suppression of Rac1 activity either by intragastric application of Rac1 inhibitor, Ehop-016, or by expression of dominant negative Rac1 rescued memory loss of APP/PS1 mice in water maze test, suggesting that increased Rac1 activity was responsible for the memory loss (Wu et al., 2019)