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Our Facility Coming Down: 6 to 24 Hours Serotonin depletion: MDMAs forced serotonin release depletes presynaptic serotonin stores over the course of the high, and as MDMA plasma levels fall below the threshold for clinical effect, serotonin-depleted neurons generate low mood, fatigue, and irritability that define the immediate comedown

doi: 10.1172/JCI19246 23 ShoelsonSEHerreroLNaazA

Ast/Alt ratio as a significant predictor of the incidence risk of prostate cancer

Starting low and escalating gradually produced fewer gastrointestinal side effects than starting directly at a higher dose, which is why the 2mg +2mg-every-4-weeks schedule became the standard escalation approach in the published data