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In this cycle, vitamin B 12 is a necessary cofactor for methionine synthase, an enzyme involved in the methylation of homocysteine to methionine

J Neurochem 63: 13711376

When this enzyme is less active, the body may produce more pheomelanin and less eumelanin

BP isoflavones have been used as anticancer agent against breast cancer cells such as triple-negative breast cancer (TNBC) and restrain the activity of endogenous estrogen (177)