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Thyroid hormones directly affect how fast and how forcefully your heart beats, as well as how responsive it is to adrenaline-type signals

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doi: 10.1002/14651858.CD009281.pub3 223

Left panel (Mechanism of Action & Pharmacodynamics) : Imipramine inhibits the serotonin transporter (SERT) and norepinephrine transporter (NET), resulting in increased synaptic concentrations of serotonin and norepinephrine (dual monoamine reuptake inhibition)