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Due to aging, the skin gets rougher and fragile, becoming more prone to bruises

It has been shown that ROS builds up in the gastric carcinoma cells after exposure to 5-FU activates HIF-1-(HMGB1) signaling, which recruits M2 TAMs, which generates GDF15 (growth differentiation factor 15), and enhances fatty acid -oxidation thus increasing the chemoresistance in them [278]