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(2) limited clinical data exist, with most studies featuring short-term evaluations (weeks-months) that preclude comprehensive safety and efficacy assessment ( 9.3 Bioactive factors used in IVD repair strategies The aim of injecting seed cells into the IVD is to promote the synthesis of proteoglycan and the recovery of disc height

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It therefore seems probable that any temperature changes with NREM-REM cycles are either not present, or much less pronounced in species like humans, with large body size and small specific metabolism

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