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At this time, gut flora richness drops to a minimum, and resident symbiotic bacteria with protective functions (such as Lachnospiraceae and Ruminococcaceae) are largely replaced by bacteria of oral origin (such as Streptococcus and Veillonella ) and typical intestinal pathogens (such as Enterobacteriaceae), a phenomenon known as oralization

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10.1126/science.aan4153 Science 35 ChanE

When the tumours reached a volume of approximately 100 mm 3 , mice were randomized into two treatment groups: vehicle and palbociclib (200 mg kg 1 three times per week)