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fumigatus gliZ [14], corresponding wild-type, gliT 26933 and gliT c in the presence (A) (6 ng, pre-incubation 2 hr prior to conidial challenge) and absence (B) of gliotoxin

The acute form of the disease is characterized by the sudden onset of cardiac insufficiency, while the chronic form results in moderate-to-severe heart enlargement with varying degrees of cardiac insufficiency (52)

Treatment with the TAK1 inhibitor 5Z-7-ox suppresses cardiac fibrosis and enhances heart function in DUSP14 KO mice with cardiac hypertrophy [235]

In particular, histone deacetylases (HDACs), critical regulators responsible for post-translational modifications, are rapidly emerging (Fig