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Preclinical (animal) findings have likewise been mixed rather than conclusive

Zrate, R., Vazdekis, J., Tejera, N., Prez, J

These cells can generate huge amounts of reactive oxygen species (ROS), and ROS induce lipid peroxidation (LP), a chain reaction that affects unsaturated fatty acids located mainly in cell membranes, generating the end product malondialdehyde (MDA), which is responsible for some of the damaging effects of free radicals on DNA and cell membranes [6]

Importantly, the researchers found that supplementing the diet in the preclinical models with vitamin B12 and folic acid increased the levels of syntaxin 17 in the liver and restored its role in autophagy