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The loss of histamine in the basal ganglia region of the brain causes too much dopamine, resulting in tics.[ref] Too much histamine affects the heart: Histamine is also essential in how the heart muscle functions

Mechanistically, this beneficial effect seems to be mediated by the regulation of intracellular Ca 2+ levels by the modulation of calbindin expression, which is associated with calcium homeostasis and plays a role in the protection of dopaminergic neurons in the pathogenesis of PD (Liu et al., 2014)