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To define the molecular determinants for the preferential binding to SMRT/NCoR, we solved the crystal structure of SHARP SPOC in complex with 1S5P CTD peptide at a resolution of 1.55 (Fig

When the degradation of GS 2 Hg to Hg(SCyGly) 2 was inhibited by treatment with a specific inhibitor of GGT, this did not decrease Hg uptake, but decreased its cytotoxicity [98]

While CD-fed and HFD-fed recipients in our study did not differ in percent weight gains over the course of the experiment, most likely because HFD intake was limited in duration, obesogenic status (high BMI) and a HFD regimen share common inflammatory pathways

Deuschl, G