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Multiple clinical trials have established dosing ranges and administration protocols that optimize metabolic benefits while maintaining excellent safety profiles

Author response: We have altered the phrasing to read, Adult wildtype C57BL6/J mice were injected with TAM or matched dose (ml/kg) of vehicle (oil) for 5d. Reviewer 1 In regard to an issue raised by Reviewer 2 (below) I question whether the estrous cycle would need to be tracked