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References Hamman JJ, Kluess HA, Buckwalter JB, Clifford PS: Blood flow response to muscle contractions is more closely related to metabolic rate than contractile work

In this issue of the JCI, Nagasaki and colleagues demonstrate a role for 15LO1 in controlling redox balance and epithelial homeostasis in T2-high asthma by metabolizing AA that is esterified to membrane phospholipids

Increased TMAO levels in addition to endothelial dysfunction, vascular aging, and oxidative stresses have been shown to cause thrombotic events and platelet excitability in humans, which in turn induce atherosclerosis [69, 72]

This compensatory mechanism has a profound secondary consequence: it alters the delicate balance of amino acids in the bloodstream