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If the abovementioned is occurring, it could mean that IGF-1 administration could also lower glucose levels by suppressing hepatic gluconeogenesis, as well as improving insulin signalling in this organ, leading to IGFBP-1 suppression and overall improvement of the IGF-1/GH/insulin axis

54 It is hypothesised that systemic effects of IL-23 inhibitors may lead to a reduction of inflammation in the central nervous system, potentially reducing the occurrence of depression

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In addition, major malformations of the central nervous system originating from the neural tube, such as caudal regression syndrome, were more prevalent in the offspring of mothers with both type 1 diabetes mellitus and type 2 diabetes