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Intriguingly, although atrophied, we did not find increased cell death in the absence of Sox2 but substantially fewer cycling acinar cells, suggesting that upon ablation, these cells exit the cell cycle and undergo differentiation to produce dormant AQP5deficient acinar cells

Expected Timeline for Results Understanding realistic timelines helps set appropriate expectations and prevents premature discontinuation of what could be an effective treatment

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Nucleic acid delivery into skin for the treatment of skin disease: proofs-of-concept, potential impact, and remaining challenges