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There is aneurysmal dilation of the proximal pulmonary arteries, which may compress the major airways causing obstruction, especially in the supine position

The combination of isatuximab-Kd was further investigated in the Phase III IKEMA trial, a randomized, open-label study conducted across 16 countries in North America, South America, Europe, and the AsiaPacific region [54, 64]

PLoS One 3:e1944, PMID: 18398470 Janky R, Ogita K, Pasqualotto BA, Bains JS, Oja SS, Yoneda Y, Shaw CA (1999) Glutathione and signal transduction in the mammalian CNS