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Cs-Ci 6 -Alcohol alkoxylates, advantageously ethoxylated and/or propoxylated Cio-Ci 5 -alcohol alkoxylates, particularly C 12 -C 14 alcohol alkoxylates, with an ethoxylation de gree between 2 and 10, preferably between 3 and 8, and/or a propoxylation degree between 1 and 6, preferably between 1.5 and 5, are particularly preferred

Then the NICE guidance say (as arbitrary it is on many areas e.g treatment frequency) says: "Maintenance treatment with hydroxocobalamin 1 mg intramuscularly every 3 months for life where B12 deficiency is not thought to be diet related

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Extensive and divergent effects of sleep and wakefulness on brain gene expression