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The FDA moved these peptides to Category 2 primarily due to a lack of large-scale, randomized, placebo-controlled human trials demonstrating their safety and efficacy

4 Strengths and limitations This review integrates evidence across cellular, organ, and physiological levels, highlighting autophagy pathways, hormonal regulation involving GH, cortisol, insulin, leptin, and thyroid hormones, as well as cardiovascular, neurological, and gastrointestinal outcomes

Methods: MASH was diagnosed based on the presence of metabolic dysfunction and steatohepatitis

This receptor profile has unique physiological effects, such as a noticeable decrease in stomach motility and brainstem-mediated signals of fullness